How should children with peanut-Allergy treated?
In recent times there’s been some statements about the fact that children with a peanut Allergy should gradually increase your intake of peanuts, to reduce the Severity of the disease. According to the latest findings, such a step can increase increase the disease but even.
In a recent study by McMaster University, it was found that a gradual increase in peanut consumption in children with a peanut Allergy, the Severity of the disease may increase. The results of the study were published in the English journal “The Lancet”.
Oral peanut immunotherapy tripled the anaphylaxis eighth-Rate
Past studies on the problems with food have shown that oral immunotherapy, in course of time, the allergen dose is gradually increased, can be quite effective. The latest research results of the McMaster University, however, doubts about this approach. It showed that Attempts to desensitize children in the real world, promote allergic reactions, including severe and potentially fatal anaphylaxis, as compared with the complete avoidance of contact with peanuts. The researchers found that oral peanut immunotherapy eighth, the anaphylaxis Rate of about 7.1 percent to 22.2 percent, tripled. Allergic reactions, vomiting, abdominal pain, itching in the mouth, hives and Asthma, and led to also took.
Safety of oral immunotherapy needs to be improved
Numerous studies of varying quality have been published for oral immune therapy, the effectiveness and reliability of treatment is, however, unclear, explain the authors of the current study. The new study includes all of the previous randomized clinical studies in which the oral peanut therapy with a non-conducted immunotherapy was compared, in order to obtain the best possible evidence for decision-making. It showed that current oral non-immune reach therapeutic approaches for peanuts the immunological target of the desensitization, however, this leads to the desired goal of avoiding the allergic reaction and of anaphylaxis will be achieved.
Instead, the opposite occurs, with more allergic and adverse reactions to oral immunotherapy, compared to avoiding contact with peanuts or taking a placebo, explain the authors of the study. The observed results do not condemn the current research therapy work in the area of the oral immune, but the method must be more carefully examined, the safety is improved and the factors of success should be the Wish of the people involved, report the researchers.
Many allergies can be overcome in the course of early life
In Europe and North America more than six million people of food allergies are affected, including eight percent of children and two to three percent of the adult. While allergies to milk and Egg at the age of five to ten years are often overcome, can be the peanut Allergy is a lifelong Problem for those Affected. Studies on oral immune therapy to measure the success of the treatment, whether a Patient tolerates a supervised contact to the Allergen. However, this can not say the future of risk in the real world, emphasize the researchers.
Oral or epicutaneous immunotherapy?
The results of the oral (through the mouth) and the epicutaneous (skin contact) immune therapy should be compared. Although the epicutaneous immune therapy less effective, it has a better safety profile than the oral immune therapy, explain the researchers. It should not be forgotten that the early introduction of peanut products in the infant food can prevent most cases of peanut allergies. There is a need for better strategies developed to reduce the number of patients with an existing peanut Allergy. (as)