Connection between Obesity and cancer: confirmation for colorectal cancer
For years, it is known that Obesity increases the risk of cancer. However, this correlation does not apply for all types of cancer. For intestinal cancer, he was able to be confirmed again. However, in the case of cervical cancer, there is now a counter-proof.
Obesity favors the development of cancer
Although there are still many types of cancer, the trigger is not known, but “we have come to know many of the factors that can trigger different cancers – but not necessarily must,” writes the Bavarian cancer society on their website. To protect yourself against cancer, it is recommended, among other things, fat the body to avoid impairment. Because of Obesity, the risk of at least 13 different types of cancer, including breast and colorectal cancer is increasing, according to a British study. The connection between Obesity and uterine cancer, there are now new findings.
Increased Colorectal Cancer Risk
According to health experts, Obesity is one of the most important rules to protect against colon cancer.
Who is to thick, according to popular belief, but it is not only an increased risk of colon but also for cervical cancer.
According to a new study by the Medical University of Innsbruck, this often confirmed connection needs to be seen now, however, under the new sign.
The researchers from the medical statistician Hanno Ulmer could not demonstrate that of Obesity increased and the insulin resistance relevant TyG (triglyceride and glucose)-the Index says the risk for tumors in the digestive tract, but the risk for gynecological cancers.
The current doctrine of non-contradictory knowledge
In a communication from the Austrian Uni is written, endometrial cancer (uterine cancer) fat “nothing to do with high blood and Sugar levels”.
This is the surprising, the current doctrine of non-contradictory knowledge of a recently in the journal “International Journal of Epidemiology” study published under the direction of Hanno Ulmer and Joseph Fritz, of the Medical University of Innsbruck, in the framework of the European cooperation project „Me-Can“ (Metabolic syndrome and Cancer) was performed.
The results will also be presented at the annual meeting of the American society for clinical Oncology (ASCO 2019) at the beginning of June in Chicago.
With Obesity-associated cancer cases
Metabolic factors such as obesity (obesity), high blood pressure, altered blood fat levels or insulin resistance have been associated with cancers already in the context.
So gastrointestinal forms of cancer, for example, such as the colon, liver and kidney cancer, but also the emergence of gynecological tumors with Obesity and the associated insulin resistance in conjunction.
In the Austrian study, the data of more than 500,000 participants from six different European cohorts were compiled and analyzed, which were, on average, observed for 17 years with regard to their life-style occurring cancer diseases.
In this period it came to 16,000 known to contribute to Obesity-associated Cancer, such as intestinal-, liver-, kidney-, pancreas – and gallbladder cancer (gastrointestinal tumors), and uterine and ovarian cancer and post-menopausal breast cancer (gynecological tumors).
“To be able to possible causal relationships present, we have a new measure, the TyG Index,” the leading study authors Josef Fritz and Hanno Ulmer.
“Of these special metabolism-a Marker is the product of triglyceride and glucose, and thus, an easily available measure of insulin resistance, which is also true to a large degree with the gold standard for the determination of insulin resistance, the Clamp-Test, are the same,” the scientists explain.
In professional circles, the insulin resistance, so the reduced sensitivity of body cells to the hormone Insulin, and precursor of type II Diabetes will be discussed, as an explanation for the connection between Obesity and cancer.
Because the growth-stimulating hormone Insulin stimulates cell division and can, therefore, also favour the growth of the tumour.
Confirmation for colorectal cancer, evidence for cervical cancer
Obesity is often associated with elevated triglyceride and glucose values.
“The results of our multicentre cohort study,” says Ulm, “a high TyG Index correlated significantly with an increased risk of gastrointestinal tumors. In addition, the TyG Index explains about 25 percent of the impact of Obesity on cancer development.“
The researchers can thus kidneys are a strong confirmation for the carcinogenic effect of Obesity on liver, -, -, pancreatic – and colon cancer provide.
However, a second finding from the study is a Surprise.
Contrary to in the medical literature represented view, to develop what is the probability of endometrial carcinoma (uterine cancer) or post-menopausal breast cancer in women with insulin resistance is significantly increased, could not confirm the research team of this connection.
“Gynecological cancers are associated with Obesity, but not with the TyG Index can be explained,” says Ulmer.
“This means increased blood fat and blood sugar values which are in no causal connection with the emergence of gynecological tumors. The influence of Estrogens on the occurrence of Cancer is likely to be greater than assumed.“ (ad)