How gut bacteria could help boost physical performance: Athletes have more of microbe ‘Veillonella’ than lazy people – and experts hope it could one day be used in a supplement
- Bacteria Veillonella break down lactic acid into the fatty-acid propionate
- Propionate maximises athletic performance, but how is unclear
- Veillonella was only in the stool samples of athletes, not ‘sedentary people’
Athletes have much higher quantities of a specific bacteria in their guts than lazy people, research has found.
Scientists compared the stool samples of 15 athletes who ran the Boston Marathon and ‘sedentary’ people.
Veillonella bacteria was abundant in the guts of the athletes. However, the bacteria was significantly less common in the other humans.
Experts now believe the bacteria enhance exercise capacity and hope the findings could lead to a probiotic supplement in future.
Researchers at the Joslin Diabetes Center, Boston, say a supplement would help those who struggle to exercise, such as type 2 diabetics.
Veillonella break down lactic acid, which causes ‘a stitch’ during strenuous activity, into the fatty-acid propionate, the scientists found.
The body is thought to use propionate to maximise its athletic performance – tests on mice showed it improved their exercise capacity.
Specific bacteria reside only in the guts of athletes and enhance their ability to exercise (stock)
Dr Aleksandar Kostic, assistant investigator, said: ‘The microbiome is such a powerful metabolic engine.
‘What we envision is a probiotic supplement that people can take that will increase their ability to do meaningful exercise.’
He added that this would ‘therefore protect them against chronic diseases including diabetes’, heart disease and an early grave.
The microbiome is linked to many disorders, including inflammatory bowel diseases, autoimmune conditions, and even obesity.
However, how microscopic bugs in the gut influence wellbeing is poorly understood, the researchers wrote in the journal Nature Medicine.
Exercise has long been recognised as being crucial to overall health, particularly that of our hearts.
However, many people with cardiovascular diseases or type 2 diabetes struggle to stay active.
The researchers therefore set out to uncover whether our microbiomes influence our ability to stay fit.
This began in 2015, when the academics collected faecal samples from 15 runners of the Boston Marathon.
Samples were gathered every day of the weeks before and after the race. They were compared against samples collected from 10 sedentary individuals.
‘One of the things that immediately caught our attention was this single organism, Veillonella, was clearly enriched in abundance immediately after the marathon in the runners,’ Dr Kostic said.
‘Veillonella is also at higher abundance in the marathon runners [in general] than it is in sedentary individuals.’
To confirm their findings, the researchers supplemented mice with Veillonella that was isolated from the runners’ stool samples.
Five hours later, the rodents were made to ‘run to exhaustion’ on a treadmill.
The animals given Veillonella had a ‘statistically significantly longer maximum run time’ than the mice not supplemented with the bacteria.
‘As we dug into the details of Veillonella, what we found was it is relatively unique in the human microbiome in that it uses lactate or lactic acid as its sole carbon source,’ Dr Kostic said.
Lactic acid is the waste product produced during strenuous exercise that causes painful cramps.
WHAT IS LACTIC ACID?
Lactic acid causes the painful cramps many people experience while exercising strenuously.
During intense physical activity, such as running, cells get the energy they need from glucose.
This energy is transferred to cells without oxygen.
The only waste product of this reaction is lactic acid.
When someone runs very fast, lactic acid builds up in their muscles, which causes a ‘stitch’.
They will then start breathing quickly in order to give their body ‘extra’ oxygen.
This oxygen reacts with lactic acid in the muscles, which causes it to break down into carbon dioxide and water.
As the lactic acid breaks down, the cramps begin to disappear.
Lactic acid is also in the mouth, where bacteria convert glucose and other sugars into the acid.
Without good oral hygiene, this can lead to tooth decay.
Source: BBC Bitesize
‘Our immediate hypothesis was [Veillonella] worked as a metabolic sink to remove lactate from the system, the idea being that lactate build-up in the muscles creates fatigue,’ Dr Kostic said.
‘But apparently this idea that lactate build-up causes fatigue is not accepted to be true. So, it caused us to rethink the mechanism of how this is happening.’
The researchers then ran a genetic analysis on 87 stool samples from ultra-marathon runners and Olympic trial rowers, both before and after exercise.
It involved tracking the genetics of all the organisms to determine any events that triggered Veillonella to break down lactic acid.
The researchers noted enzymes that are associated with lactic acid’s conversion into propionate peaked after activity.
‘Then the question was maybe it’s not removal of lactic acid, but the generation of propionate,’ Dr Kostic said.
‘We did some experiments to introduce propionate into mice [via enema] and test whether that was sufficient for this increased running ability phenotype.’
Dr Kostic added: ‘And it was. It’s very clear. It creates this positive feedback loop.
‘The host is producing something that this particular microbe favors. Then in return, the microbe is creating something that benefits the host.
‘This is a really important example of how the microbiome has evolved ways to become this symbiotic presence in the human host.’
Dr Kostic has spun off the idea of a Veillonella supplement to a company that targets athletes.
The bacteria will need to be administered via a probiotic capsule rather than direct dosing to prevent it being broken down by a person’s digestive juices.
Tim Spector, professor of genetic epidemiology at King’s College London, welcomed the findings of the study.
He said: ‘This is an exciting study showing that gut microbes and their metabolites have a role in strenuous exercise.
‘We will need more human studies to show if it is really worth taking supplements though.’
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